Arteriosclerosis in Parkinsonism

Arteriosclerosis in Parkinsonism.

Some textbooks on general and neurological medicine give the impression that cerebral arteriosclerosis is an important cause of Parkinsonism (e.g., Alpers, 1945; Yater, 1949; Purves-Stewart and Worster-Drought, 1952; Wilson, 1955; Cecil and Loeb, 1959; Grinker, Bucy, and Sahs, 1959; Merritt, 1959; Baker, 1962; Brain, 1962). Whether or not this is so, it is often very difficult to distinguish cl...

Spontaneous Arteriosclerosis in Rabbits

Experimental Arteriosclerosis

Arteriosclerotic lesions have been produced in monkeys (Macaca nemestrina) by selective removal of the vascular endothelium with an intra-arterial balloon catheter. Immediately after de-endothelialization a platelet layer covers the denuded area. This thrombus is gradually removed and by 7 days the vessel appears to be largely reendothelialized. Beginning at day 4, smooth muscle cells undergo m...

Cerebral arteriosclerosis.

Molecular biology in arteriosclerosis research.

The topics discussed in this article illustrate how molecular biology will have a dramatic impact on arteriosclerosis research. DNA clones for a small number of relevant proteins have been isolated, and studies are underway in numerous laboratories to extend these initial studies. The techniques of molecular biology will provide major advances in our understanding of numerous proteins directly ...